![]() It is based on a saponin extracted from the soapbark tree (Quillaja saponaria). Matrix-M is the adjuvant used by Novavax. In this vaccine, soapbark tree extract adjuvant makes achieving immunity possible with a smaller dose of the spike protein. What does the adjuvant (soapbark tree extract) do?Īdjuvants increase the immune response to a vaccine. Influenza vaccines have also used this moth cell factory method. "The vaccine technology is more traditional, and it's very similar to a protein-based influenza vaccine." "The Novavax vaccine has no genetic material, only proteins," says Dr. Researchers extract and purify the spike proteins.These moth cells create lots of spike proteins.The baculovirus infects moth cells and replicates inside them.Researchers put the genes into a baculovirus, an insect virus. ![]() Researchers select the desired genes that create certain SARS-CoV-2 antigens (spike protein).The Novavax method uses moth cells to make spike proteins: This vaccine doesn't contain either live or inactivated virus. Like other COVID-19 vaccines, Novavax does not cause COVID-19 infection. "All the synthesis happens outside the body and we just give the end product: the spike protein." "Unlike mRNA vaccines, the spike protein is already premade in the Novavax vaccine. This gives you protection against future COVID-19 infection. When your immune system encounters the lonely spike protein, it produces antibodies against it. All alone, the spike protein is harmless and can't cause COVID-19. The Novavax vaccine uses a telltale piece of the coronavirus: the notorious spike protein. An adjuvant is an ingredient added to boost a person's immune response, creating higher levels of antibodies. The Novavax COVID-19 vaccine contains a protein (made using moth cells) plus an adjuvant (made from tree bark). There's no polyethylene glycol (PEG) in Novavax. "Some might not accept mRNA vaccines, while others may be allergic to certain ingredients."įor example, some are allergic to polyethylene glycol (PEG), an ingredient in the mRNA (Pfizer and Moderna) vaccines. "Diversity in vaccine production helps increase the number of patients vaccinated," says Dr. Infectious diseases expert Diana Florescu, MD, led the phase 3 clinical trial of the Novavax vaccine at the University of Nebraska Medical Center (UNMC). Instead of an mRNA vaccine (Pfizer, Moderna) or a viral vector vaccine (Johnson & Johnson), Novavax is a subunit protein vaccine. Called Novavax, it's a more traditional vaccine that uses moth cells and tree bark. A fourth COVID-19 vaccine has been authorized in the United States. ![]()
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